@EyeRunMD I had a score of 364 at age 53 (I'm 55 now). Like you, I was surprised and immersed myself gathering knowledge to understand this issue. For what it's worth, here's the Cliff Notes version of some key learnings:
1. LDL isn't the best metric for identification of heart disease, it's actually the number of LP(a) particles as the primary driver. Amgen has a drug in a clinical trial to reduce LP(a) and thus slow the progression of coronary artery disease (CAD). I don't want to get too technical here, so here's a link about it if you want to read up:
https://www.amgen.com/...w-about-lipoproteina 2. PSK9 Inhibitors is the only treatment know to reduce LP(a) concentration, but most insurance won't pay for it, so the best alternative option is a statin that reduces your total LDL number. Interestingly, statins increase the LP(a) concentration; however, this risk is overwhelmed by the benefit of total LDL decrease. For what it's worth, my cardiologist has me on 40mg of Rouvastatin and 10mg of Ezetimibe to keep my LDL under 70. And yes, I take CoQ10 to offset muscle fatigue.
3. People who exercise generally have better plaque composition. There's a ton of research in this area using athletes over age 50, but my takeaway was the process of exercise functions similar to a statin in that it turns soft plaque into a safer denser plaque. It's the dense plaque that gets shown in your calcium score, not the soft plaque, so ironically people with a lower calcium can in some cases be at more risk. Lastly, athletes tend to build collateral pathways to promote blood flow leading to my next finding.
4. Stress test results and METS achieved have prognostic charts similar to calcium score charts. Based on my calcium score, I was in the bottom 5% with the highest risk. Based on my stress test, I'm at the top 5% with the lowest risk.
Overall, I think there's A LOT still being learned about CAD in athletes, but exercise serves as a protective mechanism which could enable us to live to be 100 years old with arteries full of dense calcium. Perhaps even taking a statin is redundant and unnecessary, but we aren't far enough along our learning cycle to say that with confidence. It sucks that you were dealt a bad hand, but realize it's not all gloom and doom. Just keep doing what you enjoy and follow your cardiologist's advice to slow the progression of the disease and calcify the soft plague. Good luck!